头孢菌素类抗生素是目前用于治疗感染性疾病的一种主要抗菌药.然而其疗效由于耐药菌株的扩散而受限.致病菌对β-内酰胺类抗生素(包括头孢菌素)的耐药机制有如下三种:(1)改变β-内酰胺类抗生素作用的靶位点,降低药物与青霉素结合蛋白(PBPs)的亲和力;(2)细菌细胞外膜渗透性降低;(3)抗生素分子被细菌产生的β-内酰胺酶(简称β-lase)水解. Cephalosporins are currently a major antibacterial for the treatment of infectious diseases, however, their efficacy is limited by the spread of drug-resistant strains. Pathogens have been shown to inhibit the development of β-lactam antibiotics (including cephalosporins) There are three mechanisms of drug resistance: (1) changing the target site of β-lactam antibiotics, decreasing the affinity of the drug for penicillin-binding proteins (PBPs), (2) decreasing the permeability of bacterial extracellular membranes, and (3) Antibiotic molecules are hydrolysed by bacterial-producing beta-lactamase (beta-lase).