细胞色素P450 2E1(cytochrome P450 s2E1,CYP2E1)是人体内重要的Ⅰ相代谢酶类,主要参与N-亚硝酸类化合物、黄曲霉毒素AFB_1、苯、四氯化碳等多种低分子量化合物的代谢活化。因CYP2E1参与多种前致癌物和前毒物的代谢,近年来有关其基因多态性与肿瘤易感性的关系日益成为肿瘤病因学的研究热点。本文就CYP2E1基因多态性及其与肿瘤易感性关系作一简要综述。 Cytochrome P450 2E1 (CYP2E1) is an important phase I metabolizing enzyme in the human body and is mainly involved in the metabolism of various low molecular weight compounds such as N-nitroso compounds, aflatoxin AFB_1, benzene, carbon tetrachloride and the like activation. Because CYP2E1 is involved in the metabolism of a variety of procarcinogens and pre-poisons, the relationship between its gene polymorphism and tumor susceptibility has become a hot research topic of tumor etiology in recent years. In this paper, a brief overview of CYP2E1 gene polymorphism and its relationship with tumor susceptibility.