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复合口服避孕药(COC)主要通过抑制垂 体发挥作用,服药不久出现卵泡发育受限,服药间歇期垂体抑制减轻使卵泡立即恢复。这种抑制是剂量依赖性的。本研究检验不同年龄妇女COC治疗期的卵巢活性以明确不同方案是否更适于较年长妇女。 受试者来自南曼彻斯特大学工作人员,为18～45岁、无低生育史的35例健康妇女。要求她们纳入研究前6个月月经规律,周期为25～35 d,未服OC、无妊娠和哺乳史。研究期间使用屏障避孕。所有妇女经一个对照周期检查确证有排卵,仅纳入超声诊断为排卵及黄体期血清孕酮>30pmol/L的妇女。
Compound oral contraceptives (COC) mainly through the inhibition of pituitary gland play a role, soon after administration of follicular development is limited, medication intermittent pituitary suppression so that follicles immediately restored. This inhibition is dose-dependent. This study examined the ovarian activity of COC-treated women of different ages to determine whether different regimens were more appropriate for older women. Subjects from the University of South Manchester staff, aged 18 to 45, 35 healthy women without a low birthrate. Asked them to be included in the study 6 months before the menstrual cycle, a period of 25 ~ 35 d, did not take OC, no pregnancy and lactation history. Barrier contraception was used during the study. All women were confirmed ovulation on a control cycle and included only women with ovulation and luteal phase serum progesterone> 30 pmol / L by sonography.