扁桃酸乙酯是合成脑功能轻度调节剂匹莫林(pemoline)的中间体,它是由扁桃酸和乙醇以硫酸、氯化氢为催化剂或甲苯带水酯化而得,我们采用以上常规酯化法进行了系统实验,收率均未超过80%,其中以硫酸为催化剂或甲苯带水酯化的产物中尚有两个副产物,一为固体化合物;另一为液体,它的沸点和扁桃酸乙酯相近,用常规减压分馏法很难将它从产物中除去,影响了扁桃酸乙酯的产量和质量。为此我们摸索了酯化条件与这两个副产 Ethyl mandelate synthesis of brain function is a mild regulator of pemoline (pemoline) intermediates, which is mandelic acid and ethanol with sulfuric acid, hydrogen chloride as catalyst or toluene with water esterification derived, we use the above conventional esterification France conducted a systematic experiment, the yield was not more than 80%, of which sulfuric acid as a catalyst or esterification of toluene with water there are two by-products, one for the solid compound; the other is a liquid, its boiling point and almond Ethyl acetate similar, it is difficult to remove it from the product by conventional vacuum fractionation, affecting the yield and quality of ethyl mandelate. To this end we explored the esterification conditions and these two byproducts