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神经系统变性疾病是一类由成熟神经元进行性变性、坏死所引起认知及行为异常的疾病,严重时会导致患者死亡,目前尚无有效的治疗手段。有研究表明,免疫应答异常普遍存在于中枢神经系统变性疾病过程中,并会导致蛋白质脑源性神经营养因子(BDNF)的减少,引起运动、认知及记忆等障碍。BDNF在神经系统变性疾病中免疫应答异常的作用可能涉及多种机制,虽然目前尚无定论,但BDNF相关的治疗手段,有可能从调节机体免疫能力的角度,为神经系统变性疾病的治疗提供新思路,有着重大的意义。因此,有关BDNF介导的免疫反应在神经系统变性疾病中作用的研究已成为近年来的热点。本文就此进行探讨,并对与BDNF相关的神经系统变性疾病的治疗手段进行综述。
Nervous system degenerative diseases are a group of diseases caused by the progressive degeneration and necrosis of mature neurons caused by cognitive and behavioral abnormalities. In severe cases, they can cause death and no effective treatment is available. Studies have shown that an abnormal immune response is common in central nervous system degenerative diseases and leads to a decrease in brain-derived neurotrophic factor (BDNF), causing disorders such as motor, cognition and memory. BDNF in nervous system degenerative diseases abnormal immune response may involve a variety of mechanisms, although there is no conclusion, but BDNF-related treatment may be from the perspective of regulating immune function, for the treatment of neurodegenerative diseases provide a new Ideas, has great significance. Therefore, the research on the role of BDNF-mediated immune response in neurodegenerative diseases has become a hot spot in recent years. This article discusses this and reviews the treatment of neurodegenerative diseases associated with BDNF.