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本文报告1例应用吡嗪酰胺引起的惊厥。男,2岁,出生9～12个月间,因患肺结核曾用异烟肼和氨基水杨酸治疗,并用链霉素治疗1个月。19个月时,X 线检查发现右肺上叶有一密度增高阴影,胃冲洗液培养发现结核菌。随即给予异烟肼100mg/d 和利福平150mg/d。但2个月后,因发现对异烟肼耐药,将治疗方案改为吡嗪酰胺250mg/d,利福平150mg/d。应用此方案6周后,胃冲洗液培养结核菌阴性,2周后患儿出现惊厥,伴有四肢阵发性痉挛和颈部后挺,每次持续3～5秒。患儿发作前有预兆,发作期
This article reports 1 case of pyrazinamide-induced convulsions. Male, 2 years old, born 9 to 12 months, had been treated with isoniazid and aminosalicylate for tuberculosis and treated with streptomycin for 1 month. At 19 months, the X-ray showed a density-increasing shadow in the upper lobe of the right lung and M. tuberculosis was found in the gastric irrigating fluid. Isoniazid 100mg / d and rifampicin 150mg / d. However, after 2 months, because of its resistance to isoniazid, the treatment regimen was changed to pyrazinamide 250 mg / d and rifampicin 150 mg / d. 6 weeks after application of this regimen, the gastric irrigating solution was negative for Mycobacterium tuberculosis. After 2 weeks, the child developed convulsions accompanied by paroxysmal spasms and posterior neck. Each lasted 3 to 5 seconds. There are signs of attack before the child, the attack period