Line-field confocal optical coherence tomography for three-dimensional skin imaging

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This paper reports on the latest advances in line-field confocal optical coherence tomography (LCOCT),a recently invented imaging technology that now allows the generation of either horizontal (x × y) section images at an adjustable depth or vertical (x × z) section images at an adjustable lateral position,as well as three-dimensional images.For both two-dimensional imaging modes,images are acquired in real-time,with real-time control of the depth and lateral positions.Three-dimensional (x × y × z) images are acquired from a stack of horizontal section images.The device is in the form of a portable probe.The handle of the probe has a button and a scroll wheel allowing the user to control the imaging modes.Using a supercontinuum laser as a broadband light source and a high numerical microscope objective,an isotropic spatial resolution of~1 μm is achieved.The field of view of the three-dimensional images is 1.2 mm × 0.5 mm × 0.5 mm (x × y × z).Images of skin tissues are presented to demonstrate the potential of the technology in dermatology.
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