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目的研究甲状腺乳头状癌组织中Src的表达与中央区淋巴结转移及其他临床病理特征的相关性。方法采用组织芯片和免疫组织化学技术对88例甲状腺乳头状癌患者组织标本中的Src进行检测。采用卡方检验分析Src的表达与甲状腺乳头状癌临床病理特征的关系,采用Logistic回归模型分析中央区淋巴结转移的危险因素。所有数据分析均使用SPSS 22.0统计软件。结果 88例甲状腺乳头状癌组织中Src阳性率为43.2%,在中央区淋巴结转移阳性组,Src阳性率为65.0%,卡方检验结果表明Src的表达与中央区淋巴结转移、TNM分期显著相关(均P<0.05),Src的表达与年龄、性别、肿瘤大小、癌灶多少、甲状腺包膜浸润无相关关系(均P>0.05)。Logistic回归分析结果显示Src阳性是甲状腺乳头状癌中央区淋巴结转移的独立危险因素(P<0.05)。结论 Src的表达与甲状腺乳头状癌中央区淋巴结转移密切相关,检测Src表达水平可能有助于临床决策,Src抑制剂或可作为甲状腺乳头状癌术后颈部淋巴结复发和转移的新型靶向治疗药物。
Objective To investigate the relationship between Src expression and lymph node metastasis and other clinicopathological features in papillary thyroid carcinoma. Methods Tissue microarray and immunohistochemistry were used to detect Src in 88 cases of thyroid papillary carcinoma. The relationship between Src expression and clinicopathological features of papillary thyroid carcinoma was analyzed by chi-square test. Logistic regression model was used to analyze the risk factors of lymph node metastasis in central region. All data analysis uses SPSS 22.0 statistical software. Results The positive rate of Src in 88 cases of papillary thyroid carcinoma was 43.2%. The positive rate of Src in the positive lymph node metastasis was 65.0%. The chi-square test showed that the expression of Src was significantly correlated with lymph node metastasis and TNM stage in central region (All P <0.05). There was no correlation between the expression of Src and age, sex, tumor size, tumor size and thyroid capsule infiltration (all P> 0.05). Logistic regression analysis showed that Src positive was an independent risk factor for lymph node metastasis in the central region of papillary thyroid carcinoma (P <0.05). Conclusion The expression of Src is closely related to the lymph node metastasis in the central region of papillary thyroid carcinoma. Detecting Src expression level may be helpful for clinical decision-making. Src inhibitor may serve as a new targeted therapy for cervical lymph node recurrence and metastasis of papillary thyroid carcinoma drug.