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目的:探讨血C-反应蛋白(CRP)与纤维蛋白原(FIB)联合检测对心绞痛患者心血管病事件发生的预测价值。方法:临床纳入冠心病(CHD)患者100例,根据患者心绞痛的发病类型分为稳定型心绞痛(SAP)组(50例)以及不稳定型心绞痛(UAP)组(50例),同时纳入50例健康体检者作为对照组。分别检测各组患者血液中CRP以及FIB水平。患者出院后对其进行为期3个月的临床随访,观察3个月内SAP与UAP组患者心血管事件的发生情况。结果:SAP组CRP与FIB水平分别为(3.10±0.53)mg/L、(3.45±0.37)g/L,UAP组CRP与FIB水平分别为(5.63±0.76)mg/L、(4.30±0.43)g/L,对照组CRP与FIB水平分别为(2.55±0.35)mg/L、(2.63±0.20)g/L。SAP组与UAP组CRP、FIB水平均明显高于对照组(P<0.05),UAP组CRP、FIB水平均明显高于SAP组(P<0.05);UAP组3个月内心血管事件发生率为81.08%,SAP组3个月内心血管事件发生率为21.21%,差异有显著性(P<0.05);联合检测发现CRP与FIB水平均升高的患者,3个月内心血管事件的发生率显著高于CRP与FIB均正常者(P<0.05)。结论:CRP与FIB水平与CHD心绞痛患者的严重程度有着密切的关系,而进行CRP与FIB联合检查,能够预测心血管病事件的发生。
Objective: To investigate the predictive value of the combination of serum C-reactive protein (CRP) and fibrinogen (FIB) in the diagnosis of cardiovascular events in patients with angina pectoris. Methods: One hundred patients with coronary heart disease (CHD) were randomly divided into stable angina pectoris (SAP) group (50 cases) and unstable angina pectoris group (50 cases) according to the type of angina pectoris. Fifty cases Healthy people as a control group. The blood levels of CRP and FIB in each group were detected. After discharge, the patients were followed up for 3 months. The incidence of cardiovascular events in patients with SAP and UAP within 3 months was observed. Results: The levels of CRP and FIB in SAP group were (3.10 ± 0.53) mg / L and (3.45 ± 0.37) g / L, respectively. The levels of CRP and FIB in UAP group were 5.63 ± 0.76 mg / L and 4.30 ± 0.43, g / L, while the levels of CRP and FIB in control group were (2.55 ± 0.35) mg / L and (2.63 ± 0.20) g / L, respectively. The levels of CRP and FIB in SAP group and UAP group were significantly higher than those in control group (P <0.05). The levels of CRP and FIB in UAP group were significantly higher than those in SAP group (P <0.05). The incidence of cardiovascular events within 3 months in UAP group was The incidence of cardiovascular events within 3 months in SAP group was significantly higher than that in SAP group (21.21%, P <0.05). The incidence of cardiovascular events within 3 months was significantly higher in patients with elevated CRP and FIB levels Higher than CRP and FIB were normal (P <0.05). Conclusion: The levels of CRP and FIB are closely related to the severity of angina pectoris in CHD patients. However, the combination of CRP and FIB can predict the occurrence of cardiovascular events.