在许多种属动物都已证明:内源性鸦片样物质可能参与催乳素分泌的生理性调节。例如,注入外源性鸦片及鸦片样物质(包括β-内啡肽)能刺激催乳素释放,而特异的鸦片拮抗剂(纳洛酮)能阻断这种释放。纳洛酮也能降低血清催乳素的基础水平以及由紧张引起的血清催乳素升高。为了阐明β-内啡肽是否参与这一调节过程,作者实验室观察了将β-内啡肽抗血清直接注入大鼠侧脑室内对血清催乳素的影响。实验组注射高 It has been shown in many species of animals that endogenous opioids may be involved in the physiological regulation of prolactin secretion. For example, injection of exogenous opioids and opioids (including beta-endorphin) stimulates prolactin release, whereas specific opiate antagonists (naloxone) block this release. Naloxone also decreases basal levels of serum prolactin and increases in serum prolactin caused by stress. In order to elucidate whether β-endorphin is involved in this regulatory process, we observed in our laboratory the effect of injecting β-endorphin antiserum directly into the lateral ventricle of rats on serum prolactin. Experimental group injected high