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Cooking-generated fume contains large amounts of fine particle polutants with high concentration. To study the influence of the aerosol particle pollutant in kitchen, a typical format of residential kitchen in north China is selected in this paper. FLUENT software is applied to simulate interior space airflow as wel as polutant mass fraction in breathing-section and cooking-section area in the residential kitchen under different vent cases. Furthermore, occupant’s exposure to inhalable aerosol particle is obtained integrated with human inhale model and polution exposure calculation model. The results demonstrate that cooking side of respiratory region in polutant mass fraction can be significantly reduced when opening the door, but mass fraction gradient is larger in the vicinity of the stove. The average pollution exposure in the maximum value is about 90 times than that of the minimum value around the cooking personnel with the most adverse conditions in winter when the doors and windows are al closed. The research output can provide valuable reference for the further study on fine particles concentration level as wel as to determine individual intake fraction of particles generated in the process of cooking in the residential kitchen.