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目的：为了探讨ＴＧＦ－β１及其受体在肿瘤发病中的作用。方法：本文选取了３０例原发性肝癌患者的癌组织和癌旁组织，用免疫组化及核酸狭缝杂交，图像分析仪半定量的方法，从基因转录和蛋白质表达水平分析ＴＧＦ－β１及ＴＧＦ－β１受体的含量。结果：在肿瘤发生的情况下，癌细胞，癌旁组织细胞均表达ＴＧＦ－β１，后者分泌量明显高于前者，同时，癌旁有大量的ＴＧＦ－β１受体表达，而癌细胞大部分为阴性。结论：ＴＧＦ－β１受体的缺失，可能是肿瘤细胞逃避ＴＧＦ－β１抑制生长作用的方式。
Objective: To investigate the role of TGF-β1 and its receptor in the pathogenesis of tumors. Methods: In this study, we selected 30 cases of primary liver cancer and adjacent non-cancerous tissues. Immunohistochemistry, nucleic acid hybridization and image analysis were used to analyze the expression of TGF-β1 and TGF-β1 receptor content. Results: In the case of tumorigenesis, the expression of TGF-β1 in cancer cells and adjacent tissues was significantly higher than that in the former, while there was a large number of TGF-β1 receptors in the adjacent tissues. However, most of the cancer cells Negative. Conclusion: The absence of TGF-β1 receptor may be the way tumor cells escape the inhibitory effect of TGF-β1.