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高频喷射通气(HFJV)目前尚存许多未知数,甚至存在完全相反的意见,因此有必要在一定条件下研究 HFJV 对各种肺疾病的效果。因在临床上有种种限制及困难,作者复制了4种肺疾病动物模型,分别以不同的频率进行 HFJV,并以气体交换能力为重点与间歇正压通气(IPPV)作了对比研究。对象及方法杂种成犬42只,麻醉后经气管切口气管内插管,用肌松剂后行 IPPV,1次换气量(VT)10ml/kg,频率15次/min,两侧股动脉留置导管,经股静脉插入Swan-Ganz 导管至肺动脉。安置测定平均气道内压(mPaw)、平均胸腔内压(mPpl)装置。分组:A组11只,由 S-G 导管注入0.09mg/kg 油酸,制成肺水肿模型;B 组10只,向1侧胸腔内注入400～500ml 空气,制成气胸模型(肺、胸廓顺应性约减低50%);C 组:12只,持续静滴拟胆硷药0.75～1.0mg/kg/hr,制成支气管痉挛模型,使最高气道内
There are still many unknowns in HFJV and even the opposite opinions exist. Therefore, it is necessary to study the effect of HFJV on various lung diseases under certain conditions. Due to various limitations and difficulties in clinical practice, the authors copied four animal models of lung disease and performed HFJV at different frequencies, respectively, and compared them with intermittent positive pressure ventilation (IPPV) with a focus on gas exchange capacity. Subjects and Methods Forty-two adult dogs were anesthetized with endotracheal intubation via tracheal incision followed by IPPV with muscle relaxant, 10 ml / kg of primary ventilation (VT) at a frequency of 15 breaths per minute, and bilateral femoral artery indwelling Catheter, Swan-Ganz catheter into the pulmonary artery via the femoral vein. The mean mPaw and mPpl measurements were performed. Group A: 11 rats in group A were injected with 0.09 mg / kg oleic acid via SG catheter to establish model of pulmonary edema; Group B, 10 rats were infused with 400-500 ml air into one side of thoracic cavity to make pneumothorax model About 50% reduction); Group C: 12, continuous infusion of cholinergic drugs 0.75 ~ 1.0mg / kg / hr, made bronchospasm model, the highest airway