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目的 :探讨应用抗癌剂一次经股动脉插管介入灌注冲击加栓塞缓释治疗妇科恶性肿瘤的方法及疗效观察。方法 :采用Seldinger技术行单侧股动脉穿刺插管在DSA引导下实施动脉内药物灌注术 ,使顺铂溶液对肿瘤加压冲击 ;实施动脉栓塞术 ,使特制丝裂霉素C复合乳剂及 5 -FU乳性骨架阻滞剂栓塞滞留于肿瘤异生动脉 ,以达到近期冲击 ,远期缓释的抗癌作用。结果 :介入治疗症状缓解率达 96 6 6 % ,肿块消退率占 93 33% ,无明显副反应 ,随访 5个月～ 3年 ,复发 1例 ,2 9例健在 ,其中 2 4例在介入后 15～ 39天内行癌肿根治术。结论 :本法作用时间延长 ,副反应小 ,减少反复动脉插管合并症 ,避免长时置管的护理难度 ,为近、远期手术治疗提供操作方便 ,是治疗妇科恶性肿瘤的有效方法。
Objective: To explore the application of anti-cancer drugs through a femoral artery catheterization percutaneous infusion embolization and delayed release of gynecological malignant tumor treatment and observation. Methods: Seldinger technique was used to perform intra-arterial drug infusion under the guidance of DSA with unilateral femoral artery puncture cannula to make the cisplatin solution pressurize the tumor. Arterial embolization was performed to make the special mitomycin C composite emulsion and 5 -FU milk skeleton blockade embolism retention in the tumor xenografts, in order to achieve the recent impact, long-term sustained release of anti-cancer effect. Results: The response rate of interventional treatment was 96.66%, and the rate of tumor regression was 93.33%. There was no obvious side effect. The follow-up ranged from 5 months to 3 years. One case was recurred and 29 cases were alive. Among them 24 15 to 39 days underwent radical tumor surgery. Conclusion: This method has the advantages of prolonged action, less side effects, less complications of repeated arterial intubation, difficulty of long-term catheterization care, and convenient operation for proximal and distal surgical treatment. It is an effective method to treat gynecological malignant tumors.