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目的观察脑血疏口服液联合神经节苷脂治疗急性脑出血的临床疗效。方法选取2012年1月—2015年12月在连云港市赣榆区人民医院接受急性脑出血治疗的患者82例,随机分成对照组和治疗组,每组各41例。对照组患者根据出血情况静脉滴注单唾液酸四己糖神经节苷脂钠注射液,50~80 m L加入到250 m L生理盐水中,1次/d,两周之后根据患者情况减量,维持20~40 m L/d。治疗组患者在对照组的基础上口服脑血疏口服液,10 m L/次,3次/d。两组患者均连续治疗1个月。比较两组患者临床疗效、脑血肿和脑水肿量减少量、神经功能缺损程度(NIHSS)评分、改良Barthel指数(BI)评分以及日常生活能力(ADL)评分变化。结果治疗后,对照组和治疗组总有效率分别为78.05%和92.68%,两组总有效率比较差异具有统计学意义(P<0.05)。治疗后,两组患者脑血肿和脑水肿减少量均比治疗前明显减少(P<0.05);且治疗后治疗组脑血肿和脑水肿减少量比对照组的更明显(P<0.05)。治疗后,两组患者NIHSS评分比治疗前明显降低,BI和ADL评分比治疗前明显升高,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组患者上述指标评分改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论脑血疏口服液联合神经节苷脂治疗急性脑出血能有效减少患者脑血肿和脑水肿量,降低神经功能缺损程度,提高改良BI,增强日常生活能力,具有一定的临床推广应用价值。
Objective To observe the clinical effects of Naoxuesu oral liquid combined with ganglioside in the treatment of acute cerebral hemorrhage. Methods From January 2012 to December 2015, 82 patients with acute cerebral hemorrhage treated in Ganyu People’s Hospital of Lianyungang City were randomly divided into control group and treatment group, 41 cases in each group. Control group patients according to the bleeding intravenous infusion of monosialotetrahexosyl ganglioside sodium injection, 50 ~ 80 m L added to 250 m L normal saline, 1 / d, two weeks after the reduction according to patient’s condition , Maintain 20 ~ 40 m L / d. The patients in the treatment group were given oral NaoxueShu oral liquid on the basis of the control group, 10 mL / time, 3 times / d. Two groups of patients were treated for 1 month. The clinical efficacy, cerebral hematoma and brain edema reduction, NIHSS score, modified Barthel index (BI) score and daily living ability (ADL) score were compared between the two groups. Results After treatment, the total effective rate of the control group and the treatment group were 78.05% and 92.68%, respectively. The total effective rate of the two groups was statistically significant (P <0.05). After treatment, the reduction of cerebral hematoma and cerebral edema in both groups were significantly lower than those before treatment (P <0.05). After treatment, the reduction of cerebral hematoma and cerebral edema in the treatment group was more obvious than that in the control group (P <0.05). After treatment, the NIHSS scores of the two groups were significantly lower than those before treatment, and the scores of BI and ADL were significantly higher than those before treatment (P <0.05), and the scores of the above indexes in the treatment group were improved Better than the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion Naoxueshu oral liquid combined with ganglioside in the treatment of acute intracerebral hemorrhage can effectively reduce the amount of cerebral hematoma and cerebral edema, reduce the degree of neurological deficits, improve the BI and enhance the ability of daily living, and has certain clinical application value.