Mecillinam,(MPC,amdinocillin,FL1060)是一种脒基青霉素。1972年丹麦Leo药学实验室研制成功,不久即用以治疗尿路感染、伤寒和慢性支气管炎等,取得了一定的疗效~[1-3]。本品作用机制特殊,不同于其它青霉素,可与多种β-内酰胺类抗生素联合,增强其抗菌作用,扩大其抗菌谱。近年来本品与其它抗生素联合治疗多种革蓝氏阴性杆菌感染获得了良好疗效,引起了临床的重视~[3]。1981年上海第四制药厂试制成功,我们进行了实验室研究,现将本品的体外抗菌作用和临床药理报道如下。 Mecillinam, (MPC, amdinocillin, FL1060) is an amidine penicillin. 1972 Denmark Leo Pharmaceutical Laboratory successfully developed, soon to be used to treat urinary tract infections, typhoid fever and chronic bronchitis, and achieved a certain effect ~ [1-3]. This product is a special mechanism of action, unlike other penicillins, with a variety of β-lactam antibiotics combined to enhance its antibacterial effect and expand its antibacterial spectrum. In recent years, this product and other antibiotics combined treatment of a variety of gram-negative bacilli infection has received good results, causing clinical attention [3]. 1981 Shanghai Fourth Pharmaceutical Factory pilot success, we conducted a laboratory study, now the goods in vitro antibacterial effects and clinical pharmacology reported below.