大肠癌为常见恶性肿瘤。单用5-FU治疗缓解率在20～30％。其主要毒性是骨髓抑制和胃肠道反应。近年有人试用低浓度5-FU溶液长期连续灌注肠腔治疗晚期直肠癌亦取得了一定疗效。本实验采用对称二甲肼(DMH)诱发小鼠大肠癌,比较直肠灌注和腹腔注射5-FU对小鼠大肠癌的抑制作用及对小鼠的毒 Colorectal cancer is a common malignancy. Remission with 5-FU alone was 20-30%. Its main toxicity is myelosuppression and gastrointestinal reactions. In recent years, some people try low-concentration 5-FU solution continuous long-term infusion of intestinal treatment of advanced colorectal cancer also made some effect. In this study, symmetrical dimethyl hydrazine (DMH) induced colorectal cancer in mice, compared rectal perfusion and intraperitoneal injection of 5-FU on the inhibition of colorectal cancer in mice and the toxicity