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作者报道2例罕见的儿童外阴恶性黑素瘤(VMM),并强调对儿童期外阴突然发生、迅速增长的色素沉着皮损进行组织学检查的重要性。 例1,9岁,因发现右侧小阴唇有一色素沉着皮损6个月就诊,无自觉症状。患者4岁时腋窝汗液开始有气味,6岁时乳房组织和阴毛开始发育。但月经尚未来潮。无黑素瘤家族史。体检发现右侧小阴唇有一小于1cm、边界不规则、色素不均匀的棕黑色斑,皮损上方的外阴粘膜轻度发白,紧靠色素斑的上方有一局限性出血区,其余粘膜未见异常。左下肢有白癜风。例2,11岁,右侧小阴唇一色素增深性皮损,进行性增大3个
The authors reported two rare cases of malignant vulvar melanoma (VMM) in children and emphasized the importance of histological examination of sudden and rapidly increasing hyperpigmented skin lesions in childhood. Example 1, 9-year-old, was found to have a pigmented lesion on the right labia minora for 6 months without symptoms. The patient’s armpit sweat began to smell at the age of 4 years, and the breast tissue and pubic hair began to develop at the age of 6. But menstruation has not yet arrived. No family history of melanoma. Physical examination revealed that the right labia minora had brownish black spots with less than 1 cm in size, irregular borders, and uneven pigmentation. The vulvar mucosa above the skin lesions was slightly white, and there was a localized bleeding zone immediately above the pigmented spots. No abnormalities were found in the remaining mucosa. . There is vitiligo in the left lower limb. Example 2, 11-year-old, right-side labia minora with pigmented lesions, progressive increase 3