论文部分内容阅读
目的比较不同剂量替米沙坦治疗老年高血压伴慢性肾脏病的临床疗效。方法选取2014年1月-2015年12月内科收治的老年高血压伴慢性肾脏病患者60例,随机分为替米沙坦常规剂量组40mg/d和双倍剂量组80mg/d,各30例,持续治疗12周。于治疗结束后比较两组患者治疗前后血压、24h尿蛋白变化及血钾、血肌酐水平。结果两组患者治疗后血压及24h尿蛋白均有所降低,双倍剂量组降低水平更优于常规剂量组(P<0.05);双倍剂量组降低尿蛋白有效率为93.3%,高于对照组83.3%的有效率,组间比较有显著性差异(P<0.05)。结论替米沙坦是一种具有降压及保护肾脏功能作用的临床药物,选用双倍剂量应用可以进一步提高降压和减少尿蛋白的疗效。
Objective To compare the clinical effects of different doses of telmisartan in the treatment of elderly patients with hypertension and chronic kidney disease. Methods Sixty elderly patients with hypertension and chronic kidney disease admitted from January 2014 to December 2015 in our hospital were randomly divided into 40 mg / d and 80 mg / d doses of telmisartan and 30 mg , Continued treatment for 12 weeks. After treatment, blood pressure, 24h urinary protein and serum potassium and serum creatinine were compared between the two groups before and after treatment. Results After treatment, the blood pressure and 24h urinary protein decreased in both groups, and the reduction in double-dose group was better than that in conventional dose group (P <0.05). Double-dose group decreased the urine protein efficiency 93.3% Group 83.3% efficiency, there was significant difference between groups (P <0.05). Conclusion Telmisartan is a clinical drug with antihypertensive and protective effects on renal function. Doubled dosage can further reduce blood pressure and reduce urinary protein.