长链非编码RNAs(long noncoding RNAs,lnc RNAs)是一类长度大于200个核苷酸,不具有蛋白质编码功能的RNA,过去被视为转录的噪音,但近年的研究表明,它们在基因表达的调控中发挥重要作用。Lnc RNAs能在表观遗传、转录以及转录后水平多个层面发挥作用。本文概述了lnc RNAs的分类及分子作用,并综述了其在心血管疾病中的研究进展。 Long-length noncoding RNAs (RNAi), a class of RNAs longer than 200 nucleotides in length and lacking the function of protein coding, were used as the transcriptional noise in the past. However, recent studies have shown that they are important in gene expression Regulation and control play an important role. Lnc RNAs can function at multiple levels of epigenetic, transcriptional and post-transcriptional levels. This article summarizes the classification and molecular effects of lnc RNAs, and reviews its progress in cardiovascular diseases.