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目的 观察CD117在急性非淋巴细胞性白血病 (ANLL)细胞中的表达 ,评价其对白血病患者生存时间判断方面的价值。方法 采用流式细胞仪对 6 6例ANLL患者的白血病细胞进行分析。观察CD117阳性和阴性患者的预后 ,并做多因素分析。结果 6 6例ANLL患者中 ,41例表达CD117,CD117在ANLL患者中各亚型的表达差异无显著性 (P >0 .0 5 )。CD117阳性患者完全缓解 (CR)率低(43 9% ) ,CD117阴性患者CR率高 (72 0 % ) (P <0 .0 5 )。CD117阳性患者生存时间短 (196d) ,CD117阴性患者生存时间长 (30 2d) (Log Rank检验P =0 .0 0 12 )。将年龄、性别、WBC、缓解、复发、CD117阳性分别引入Cox模型和logistic回归进行多参数分析 ,结果显示CD117可能是影响ANLL患者预后的一个因素(P <0 .0 5 )。结论 在ANLL中CD117阳性表达的患者有比较差的预后
Objective To observe the expression of CD117 in acute nonlymphocytic leukemia (ANLL) cells and evaluate its value in judging the survival time of leukemia patients. Methods Flow cytometry was used to analyze the leukemic cells in 66 patients with ANLL. Observe the prognosis of CD117 positive and negative patients and do multivariate analysis. RESULTS: Among 61 patients with ANLL, 41 were found to express CD117. The expression of CD117 in ANLL patients was not significantly different (P > 0.05). CD117-positive patients had a low rate of complete remission (CR) (43 9%), and CD117-negative patients had a high CR rate (72%) (P < 0.05). The survival time of CD117-positive patients was short (196d), and the survival time of CD117-negative patients was long (30 2d) (Log Rank test P =0. 0 0 12 ). The age, sex, WBC, remission, recurrence, and CD117 positive were introduced into the Cox model and logistic regression, respectively, for multiparametric analysis. The results showed that CD117 may be a factor influencing the prognosis of ANLL patients (P < 0.05). Conclusion Patients with positive CD117 expression in ANLL have a poor prognosis