目的评价天地欣联合顺铂治疗恶性胸腔积液的疗效和毒性。方法30例恶性胸腔积液患者B超定位下注射天地欣和顺铂,观察胸水变化及毒副作用。结果总有效率为70%,不良反应主要为胃肠道反应、发热、胸痛,对症治疗可缓解。结论天地欣联合顺铂胸腔灌注能有效控制恶性胸水,缓解症状,且毒副反应轻微。 Objective To evaluate the efficacy and toxicity of Tianxinxin combined with cisplatin in the treatment of malignant pleural effusion. Methods Thirty patients with malignant pleural effusion were injected with Tianxin and Cisplatin under ultrasound B, and the changes of pleural fluid and side effects were observed. Results The total effective rate was 70%. The main adverse reactions were gastrointestinal reactions, fever, chest pain, symptomatic treatment can be alleviated. Conclusion Tianxin Xin combined cisplatin pleural perfusion can effectively control malignant pleural effusion, relieve symptoms, and minor toxic reactions.