论文部分内容阅读
目的分析RA患者肺功能损害的特点与原因。方法 :测定 39例RA患者的常规肺功能 ,设正常对照组对所得数据进行t检验及相关分析 ,同时计算各项异常的百分率及分析BUN的影响。结果 :t检验显示RA患者的DLCO/VA 明显减低、RV/TLC稍增高且与对照组相比都有显著性差异 (P <0 .0 5 ) ,VC、FVC、FEV1、MVV、DLCO均值虽在正常范围 ,但与对照组相比也有显著差异 (P <0 .0 5 ) ;相关分析显示DLCO与TLC、RV明显正相关 (r=0 .35 ,P <0 .0 5和r=0 .4 3,P <0 .0 5 )。结论 :RA患者的肺功能与健康人相比有多项显著差异 ,受损以弥散功能障碍为主 ,限制性通气障碍与阻塞性通气障碍并存且以限制性通气障碍为主 ,此外见较高比例的小气道阻塞、肺气肿和通气功能减退 ,其原因主要为肺间质受累致小气道阻塞、肺容积异常改变和肺毛细血管床减少所致 ,但TLC大幅下降的现象并未见到。
Objective To analyze the characteristics and causes of pulmonary dysfunction in RA patients. Methods: The routine pulmonary function tests were performed in 39 patients with RA. T test and correlation analysis were performed on the data obtained from the normal control group. The percentages of abnormalities and the effects of BUN were also calculated. Results: The t-test showed that the DLCO / VA of RA patients decreased significantly, RV / TLC slightly increased compared with the control group (P <0.05), while the mean of VC, FVC, FEV1, MVV and DLCO (P <0.05). The correlation analysis showed that DLCO was positively correlated with TLC, RV (r = 0.35, P <0.05 and r = 0 .4 3, P <0. 05). CONCLUSION: There are a number of significant differences in lung function among RA patients compared to healthy individuals, with diffuse dysfunction predominantly impaired and restrictive ventilatory and obstructive ventilatory disorders coexist with restrictive ventilatory disturbances as well as higher Proportions of small airway obstruction, emphysema and hypogonadism were mainly attributed to small airway obstruction involving pulmonary interstitium, abnormal lung volume, and decreased pulmonary capillary bed, but the substantial decline in TLC was not seen .