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目的:研究胃疡宁丸抗实验性胃溃疡的药效及其机制。方法:采用大鼠醋酸注射法、水浸应激性、阿司匹林诱发及幽门结扎性胃溃疡模型,观察胃疡宁丸抗胃溃疡的作用并考察其对血清NO,EGF含量,胃黏膜血流量,PGE2含量,及对胃液分泌、胃酸含量、胃蛋白酶活性的影响。结果:胃疡宁丸能够降低各种胃溃疡模型的溃疡指数,升高NO,EGF含量,PGE2含量及胃黏膜血流量,抑制胃液分泌和胃酸含量及降低胃蛋白酶活性。结论:胃疡宁丸具有明显的抗实验性胃溃疡的作用,该作用与其减少胃黏膜损伤因子(胃酸、胃蛋白酶),增加胃黏膜屏障的功能,增强胃黏膜修复作用(NO,EGF,PGE2,胃黏膜血流量)有关。
Objective: To study the efficacy and mechanism of Weiyiningning pill in treating experimental gastric ulcer. Methods: The rat model of gastric ulcer induced by acetic acid injection, water immersion stress, aspirin and gastric ulcer of pylorus was used to observe the effect of Weiyangning Pill on gastric ulcer and the effect on NO, EGF, gastric mucosal blood flow, PGE2 content, gastric juice secretion, gastric acid content, pepsin activity. Results: Weiyangning Pill could reduce the ulcer index, increase the contents of NO, EGF, PGE2, gastric mucosal blood flow, gastric juice secretion and gastric acid content and pepsin activity in various gastric ulcer models. Conclusion: Weiyangning Pill has significant anti-experimental gastric ulcer effect, which is related to its function of reducing gastric mucosal damage factors (gastric acid and pepsin), increasing gastric mucosal barrier and enhancing gastric mucosal repair (NO, EGF, PGE2 , Gastric mucosal blood flow).