消化性溃疡的发生与许多因素有关,通常认为是由于胃腔内攻击因素和保护/修复因素失去平衡所致,传统将胃酸视为最重要的攻击因素,因此,迄今的治疗主要是通过中和的方法(如抗酸药物)或药物抑制胃酸分泌(H_2受体拮抗剂、质子泵抑制剂)来降低胃酸。近年人们的观念发生了改变,幽门螺杆菌(HP)感染被视为是最重要的致病因子,因此,十二指肠溃疡可能是一种纯粹感染性疾病。 The occurrence of peptic ulcer is related to many factors and is usually thought to be caused by the imbalance of intragastric attack and protection / repair factors. Traditionally, gastric acid is regarded as the most important attacking factor. Therefore, the treatment to date is mainly through neutralization (Such as antacid drugs) or drugs that inhibit gastric acid secretion (H 2 receptor antagonists, proton pump inhibitors) to reduce gastric acid. In recent years, people’s attitudes have changed. Helicobacter pylori (HP) infection is considered to be the most important causative agent, therefore, duodenal ulcer may be a purely infectious disease.