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目的:观察氯雷他定联合甲基强的松冲击疗法治疗小儿过敏性紫癜的疗效,及其对患儿血清免疫学指标的影响。方法:将180例过敏性紫癜患儿随机分为对照组和观察组,每组各90例。所有患者均接受包括氯雷他定的基础治疗,观察组在此基础上加用甲基强的松冲击治疗。观察并比较两组的临床疗效、临床症状消失时间及治疗前后血清免疫学指标的变化情况。结果:观察组患儿治愈率和总有效率显著高于对照组,差异具有统计学意义(P<0.05);观察组临床症状消失时间显著短于对照组,差异具有统计学意义(P<0.05);治疗后,观察组患儿血清Ig A、C3、TNF-α及IL-10水平显著低于对照组,差异具有统计学意义(P<0.05)。结论:氯雷他定联合甲基强的松龙能有效抑制炎症反应,调节免疫平衡,在小儿过敏性紫癜治疗中具有积极意义。
Objective: To observe the curative effect of loratadine combined with methylprednisolone impact therapy on children with Henoch-Schonlein purpura and its effect on serum immunological parameters in children. Methods: 180 cases of children with Henoch-Schonlein purpura were randomly divided into control group and observation group, 90 cases in each group. All patients received basic therapy including loratadine, and the observation group was treated with methylprednisone. The clinical efficacy, the disappearance of clinical symptoms and the change of serum immunological indexes before and after treatment were observed and compared between the two groups. Results: The cure rate and total effective rate in the observation group were significantly higher than those in the control group (P <0.05). The disappearance time of clinical symptoms in the observation group was significantly shorter than that in the control group (P <0.05) ); After treatment, the levels of serum Ig A, C3, TNF-α and IL-10 in the observation group were significantly lower than those in the control group, with statistical significance (P <0.05). Conclusion: Loratadine combined with methylprednisolone can effectively inhibit the inflammatory response and regulate immune balance, which is of positive significance in the treatment of children with Henoch-Schonlein purpura.