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目的观察肿瘤患者血清ＴＮＦ－α的变化及临床意义。方法应用放射免疫测定法对２０例健康对照者和７０例肿瘤患者进行了血清ＴＮＦ－α含量测定。结果对照组血清ＴＮＦ－α的含量较低，肿瘤患者明显升高（Ｐ＜０．０１）；肿瘤转移和／或复发时无进一步上升，而肿瘤合并胸腹水和恶液质时ＴＮＦ－α上升明显。结论肿瘤患者血清的ＴＮＦ－α水平明显高于对照组，随着肿瘤的局部控制及消退，体内ＴＮＦ－α含量呈下降趋势，因此ＴＮＦ－α含量的变化对肿瘤患者病情变化及预后的判定，具有一定的参考价值。
Objective To observe the changes and clinical significance of serum TNF-α in tumor patients. Methods Radioimmunoassay was used to detect the serum TNF-α levels in 20 healthy controls and 70 cancer patients. Results The levels of serum TNF-α in the control group were lower, and the tumor patients were significantly elevated (P<0.01); there was no further increase in tumor metastasis and/or recurrence, while the increase of TNF-α in the tumor with pleural effusion and cachexia. obvious. Conclusion The serum level of TNF-α in tumor patients was significantly higher than that in the control group. With the local control and regression of tumors, the level of TNF-α in the body showed a downward trend. Therefore, the changes of TNF-α content in patients with tumors in patients with disease status and prognosis, Has a certain reference value.