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表面增强激光解析离子化飞行时间质谱技术是新一代蛋白质组研究技术,它使用特殊的增强表面直接捕获待测样本中的蛋白质分子,能够快速、敏感地发现并鉴定蛋白,提供一个高通量和高灵敏度的检测平台。最初主要应用于疾病早期诊断相关的蛋白质标志物。目前在预测肿瘤化疗敏感性方面的应用也逐渐增多。本文除对表面增强激光解析离子化飞行时间质谱技术做详尽的介绍外,重点阐述其在预测肿瘤化疗敏感性方面的应用,并对其优缺点和发展前景进行评估。
Surface Enhanced Laser Desorption Ionization Time of Flight Mass Spectrometry is a new generation of proteomics research technology that uses special enhanced surfaces to directly capture protein molecules in a sample to be tested, to quickly and sensitively discover and identify proteins, provide a high throughput and High sensitivity detection platform. Initially mainly used in early diagnosis of disease-related protein markers. At present, the application of predicting the chemosensitivity of tumors is gradually increasing. In addition to the surface enhanced laser desorption ionization time of flight mass spectrometry technology to make a detailed introduction, the focus on its application in the prediction of chemotherapy sensitivity of the tumor, and its advantages and disadvantages as well as the prospects for the development of assessment.