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目的探讨2型糖尿病肾病患者D-二聚体及胆红素的测定及临床意义。方法本次研究中的119例研究对象均为2014年1月~2016年3月我院收治的2型糖尿病肾病患者并将其作为观察组。对照组50例,均为同期来我院进行健康体检的健康研究对象。将观察组进行再次分组:正常蛋白尿组(NA,n=51)、微量白蛋白尿组(MA,n=43)、大量白蛋白尿组(OA,n=25)。对四组D-二聚体、TBIL、DBIL、IBIL水平进行检测及对比分析。结果观察组D-二聚体高于对照组,TBIL、DBIL、IBIL水平低于对照组,差异有统计学意义(P<0.05)。MA、OA组D-二聚体水平高于NA组,TBIL、DBIL、IBIL水平低于NA组,OA组D-二聚体水平高于MA组,TBIL、DBIL、IBIL水平低于MA组,差异有统计学意义(P<0.05)。结论 D-二聚体及胆红素对于2型糖尿病肾病患者的诊断具有重要的临床价值,有利于糖尿病肾病的早期诊断及病情的控制,使致残率及致死率降低。
Objective To investigate the determination of D-dimer and bilirubin in type 2 diabetic nephropathy and its clinical significance. Methods All 119 patients in our study were type 2 diabetic nephropathy patients who were admitted to our hospital from January 2014 to March 2016 and were included in the observation group. The control group of 50 cases, all of the same period to our hospital for health examination of the health object. The observation group was subdivided again: normal albuminuria group (NA, n = 51), microalbuminuria group (MA, n = 43), and extensive albuminuria group (OA, n = 25). Four groups of D-dimer, TBIL, DBIL, IBIL levels were detected and compared. Results The D-dimer in the observation group was higher than that in the control group, while the levels of TBIL, DBIL and IBIL in the observation group were lower than those in the control group (P <0.05). The level of D-dimer in OA group was higher than that in NA group, while the levels of TBIL, DBIL and IBIL in OA group were lower than those in NA group. The levels of D-dimer in OA group were higher than those in MA group, while the levels of TBIL, DBIL and IBIL in OA group were lower than those in NA group The difference was statistically significant (P <0.05). Conclusion D-dimer and bilirubin have important clinical value for the diagnosis of type 2 diabetic nephropathy, which is good for the early diagnosis of diabetic nephropathy and the control of the disease, so as to reduce the morbidity and mortality.