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目的:比较甘草酸二铵胶囊及其脂质复合物泡腾颗粒在小鼠体内的血和肝组织分布,探讨甘草酸二铵脂质复合物作为肝靶向药物的可行性。方法:以小鼠为实验动物,单次灌胃给予甘草酸二铵胶囊及其脂质复合物泡腾颗粒剂,剂量500 mg·kg-1,给药后30 min,1 h,2 h,4 h时取血浆及肝脏,高效液相色谱法测定血及肝脏中甘草酸二铵的浓度。结果:泡腾颗粒组小鼠血及肝组织中血药浓度显著高于胶囊组(P<0.01),肝组织中的药物浓度显著高于血中药物浓度(P<0.01),而胶囊组血及肝组织中血药浓度无统计学差异。结论:脂质复合物泡腾颗粒剂能显著提高小鼠血及肝组织中甘草酸二铵的浓度,特别是肝组织中药物的浓度,有肝靶向作用。
OBJECTIVE: To compare the distribution of blood and liver tissues of diammonium glycyrrhizinate capsules and its lipid complex effervescent granules in mice, and to explore the feasibility of using LDH lipid complex as a liver-targeting drug. Methods: The mice were used as experimental animals, single oral administration of glycyrrhizic acid diammonium capsules and its lipid complex effervescent granules at a dose of 500 mg · kg-1, 30 min, 1 h, 2 h, Plasma and liver were taken at 4 h, and the concentration of diammonium glycyrrhizinate in blood and liver was determined by high performance liquid chromatography. Results: The blood concentration in the blood and liver of the effervescent granules group was significantly higher than that of the capsule group (P <0.01), and the concentration of the drug in the liver tissue was significantly higher than that in the blood (P <0.01) There was no significant difference of plasma concentration in liver tissue. Conclusion: The lipid complex effervescent granules can significantly increase the concentration of diammonium glycyrrhizinate in the blood and liver tissue of mice, especially the concentration of the drug in liver tissue, and has the effect of liver targeting.