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目的分析苏州地区妊娠期糖尿病(gestational diabetes mellitus,GDM)与正常妊娠者早孕期血清25羟维生素D〔25-hydroxy vitamin D,25(OH)D〕水平差异,为妊娠期补充维生素D,及是否可能成为妊娠期糖尿病的潜在预防策略提供实验依据。期研究工作。方法选择2013年1月在南京医科大学附属苏州医院产科门诊进行产前保健的孕妇,分为正常妊娠组及GDM组,取妊娠13~16周孕妇血清,排除慢性肝病、甲状腺功能亢进和结缔组织疾病者。采用酶联免疫吸附法测定血清25(OH)D水平,同时计算BMI值,比较正常妊娠组及GDM组25(OH)D水平和BMI值。结果 1GDM组25(OH)D水平为(15.77±5.69)nmol/L,明显低于正常妊娠组(25.05±4.04)nmol/L(P<0.05);2GDM组BMI值为(22.95±3.77)kg/m2,对照组BMI为(21.65±4.03)kg/m2,两组比较差异均有统计学意义(P<0.05)。结论苏州地区孕妇维生素D水平普遍不足,GDM组较对照组维生素D水平更低,孕妇应该根据自身情况额外补充维生素D制剂。
Objective To analyze the difference of serum 25-hydroxy vitamin D (25 (OH) D] level between gestational diabetes mellitus (GDM) and normal pregnancy in the first trimester of pregnancy in Suzhou and to provide vitamin D for pregnancy and whether May become a potential prevention strategy for gestational diabetes to provide experimental evidence. Period of research work. Methods Pregnant women who were given prenatal care at the Obstetrics and Gynecology Clinic of Suzhou Hospital Affiliated to Nanjing Medical University in January 2013 were divided into normal pregnancy group and GDM group. Pregnant women ’s serum from 13 to 16 weeks’ gestation, excluding chronic liver disease, hyperthyroidism and connective tissue Disease. Serum 25 (OH) D levels were measured by enzyme-linked immunosorbent assay, BMI values were calculated, and 25 (OH) D levels and BMI values in normal pregnancy and GDM groups were compared. Results The 25 (OH) D level in 1GDM group was (15.77 ± 5.69) nmol / L, which was significantly lower than that in normal pregnancy group (25.05 ± 4.04 nmol / L, P <0.05) / m2 in the control group, and (21.65 ± 4.03) kg / m2 in the control group. There was significant difference between the two groups (P <0.05). Conclusion The level of vitamin D in pregnant women in Suzhou area is generally insufficient. The level of vitamin D in GDM group is lower than that in control group. Pregnant women should be supplemented with vitamin D preparations according to their own circumstances.