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目的为掌握我省脊髓灰质炎（脊灰）病毒型内抗原特征。方法应用脊灰单克隆抗体（ＭｃＡｂ）中和法进行型内抗原分析。结果湖南省１９８９～１９９１年有１０个地（市）为脊灰Ⅰ型野病毒传播，根据对ＭｃＡｂ反应的不同可分为４个类别，以ＰＩ—１最多，占７７．２７％（１７／２２），抗原性质属类强毒株。结论Ｐ１—１型为我省脊灰流行的主要型别，脊灰Ⅱ、Ⅲ型均为疫苗相关株病毒。方法能从抗原表位水平分析研究毒株的性质，鉴别疫苗株和野毒株，具有敏感特异，简单等特点
The purpose is to master the province of polio (polio) virus type endogenous antigen characteristics. Methods The intranasal antigens were analyzed by the monoclonal antibody (McAb) neutralization method. Results In 1989 ~ 1991, 10 prefectures and cities of China were poliovirus type Ⅰ wild-type virus transmission. According to the McAb response, it could be divided into 4 categories, with PI-1 up to 77.27% (17 / 22), the nature of the antigen is a class of virulent strains. Conclusions P1-1 type is the main type of polio epidemic in our province. Both poliovirus types Ⅱ and Ⅲ are vaccine-associated strains of virus. Methods The properties of the strains can be analyzed from the level of antigenic epitopes, and the vaccine strains and wild strains can be identified, which are sensitive and specific