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对于血管性移植物,同种抗原并不是局限于某个部位而是弥散地分布于多个淋巴器官,因此需要诱导系统性免疫耐受。论文报告通过静脉回输供者脾脏细胞以及抗CD40L的单抗,成功建立了同种血管性心脏移植达10周的耐受动物模型,并首次发现小鼠浆细胞样树突状细胞(pDC)具有吞噬功能,其在
For vascular grafts, alloantigen is not confined to a single site but diffusely distributed in multiple lymphoid organs and therefore needs to induce systemic immune tolerance. The paper reports the successful establishment of a tolerated animal model of allogeneic vascular grafting for 10 weeks by venous return of donor spleen cells and anti-CD40L monoclonal antibody, and for the first time found that mouse plasmacytoid dendritic cells (pDC) With phagocytic function, its in