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为探讨肾小球肾炎患者血浆Ｐ选择素水平改变的临床意义及诊断价值，采用酶联免疫吸附法（ＥＬＩＳＡ），检测１２３例各种病理类型肾小球肾炎患者血浆Ｐ选择素水平。结果显示：①肾炎患者血浆Ｐ选择素水平显著高于对照组（Ｐ＜０．００１）；②肾小球细胞增生及硬化明显者血浆Ｐ选择素水平显著高于肾小球炎症轻微者（Ｐ＜０．００１）；③肾炎患者血浆Ｐ选择素水平与其肾小管间质病变程度显著相关（ｒ＝０．５７７，Ｐ＜０．００１）。提示：肾小球肾炎患者血浆Ｐ选择素水平在一定程度上反映其肾小球内血小板活化、细胞增生及硬化情况，可能成为临床判断肾小球肾炎伴肾小管间质病变程度的一项有效指标
In order to explore the clinical significance and diagnostic value of plasma P-selectin levels in patients with glomerulonephritis, the plasma P-selectin levels were measured in 123 patients with glomerulonephritis of various pathological types by enzyme-linked immunosorbent assay (ELISA). The results showed that: ①The plasma P-selectin level in patients with nephritis was significantly higher than that in the control group (P <0.001); ② The levels of P-selectin in glomerular cells with hyperplasia and sclerosis were significantly higher than those with mild glomerular inflammation (P <0.001). ③ The plasma P-selectin level in patients with nephritis was significantly correlated with the degree of tubulointerstitial lesions (r = 0.577, P <0.001). Prompted: glomerulonephritis in patients with plasma P-selectin levels to some extent reflect the glomerular platelet activation, cell proliferation and sclerosis, may be a clinical judgment of glomerulonephritis with tubulointerstitial lesions of an effective index