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目的探讨阿司匹林联合氯吡格雷治疗心肌梗死(MI)的效果。方法以衡阳市中心医院2013年8月-2015年8月收治的80例心肌梗死患者为研究对象,按照随机数字法将其分为两组。对照组(n=40)单纯接受阿司匹林治疗,观察组(n=40)在对照组基础上联合使用氯吡格雷治疗。观察治疗过程中两组患者发生不良反应的情况,随访1年,就两组患者疗效、不良反应发生率和存活率情况展开分析。结果观察组患者治疗总有效率90.0%与对照组77.5%比较,差异有统计学意义(χ2=5.740 5,P<0.05)。观察组治疗过程中总计发生不良反应2例(5.0%),对照组4例(10.0%),差异有统计学意义(χ2=5.673 8,P<0.05)。随访1年发现,观察组存活37例(92.5%),对照组存活33例(82.5%),差异有统计学意义(χ2=4.571 4,P<0.05)。结论阿司匹林联合氯吡格雷治疗心肌梗死患者临床疗效更好,降低患者病死率,且不良反应少。
Objective To investigate the effect of aspirin plus clopidogrel in the treatment of myocardial infarction (MI). Methods Eighty patients with myocardial infarction who were treated in Hengyang Central Hospital between August 2013 and August 2015 were divided into two groups according to random number method. The control group (n = 40) received aspirin alone. The observation group (n = 40) was treated with clopidogrel in combination with the control group. Observation of adverse reactions in the two groups of patients during treatment, followed up for 1 year, the two groups of patients efficacy, adverse reactions and survival rates were analyzed. Results The total effective rate of observation group was 90.0% compared with 77.5% of control group, the difference was statistically significant (χ2 = 5.7405, P <0.05). There were 2 adverse reactions (5.0%) in the observation group and 4 cases (10.0%) in the control group, the difference was statistically significant (χ2 = 5.673 8, P <0.05). One year after follow-up, 37 patients (92.5%) in the observation group and 33 patients (82.5%) in the control group showed statistically significant difference (χ2 = 4.571 4, P <0.05). Conclusion Aspirin combined with clopidogrel in patients with myocardial infarction better clinical efficacy, reduce patient mortality, and fewer adverse reactions.