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目的观察托拉塞米联合螺内酯治疗慢性充血性心力衰竭的临床效果。方法选取医院收治的慢性充血性心力衰竭患者50例作为研究对象,随机分为观察组和对照组,每组25例。观察组采用托拉塞米联合螺内酯治疗,对照组采用呋塞米联合螺内酯治疗。观察比较2组临床治疗效果、治疗前后心功能指标变化及不良反应发生率。结果观察组治疗总有效率为92.0%,高于对照组的72.0%(P<0.05)。经过治疗后,2组SV、CI、LVEF等相关心功能指标相对于治疗前均有所升高(P<0.05),观察组治疗后各项指标变化更为显著(P<0.05)。观察组不良反应发生率为4.0%,低于对照组的20.0%(P<0.05)。结论慢性充血性心力衰竭患者采用托拉塞米联合螺内酯治疗的临床效果显著,可有效改善心功能,降低不良反应发生率,值得临床推广应用。
Objective To observe the clinical effect of torsemide combined with spironolactone in the treatment of chronic congestive heart failure. Methods Fifty patients with chronic congestive heart failure admitted to hospital were selected as study subjects and randomly divided into observation group and control group with 25 cases in each group. The observation group was treated with torsemide combined with spironolactone and the control group with furosemide combined with spironolactone. Observed and compared two groups of clinical treatment effect, changes in cardiac function before and after treatment and the incidence of adverse reactions. Results The total effective rate in the observation group was 92.0%, which was higher than that in the control group (72.0%, P <0.05). After treatment, the relative indexes of cardiac function such as SV, CI, LVEF and so on in the two groups were higher than those before treatment (P <0.05). The indexes in the observation group changed more significantly after treatment (P <0.05). The incidence of adverse reactions in the observation group was 4.0%, which was lower than 20.0% of the control group (P <0.05). Conclusion The clinical effect of torsemide combined with spironolactone in patients with chronic congestive heart failure is significant, which can effectively improve cardiac function and reduce the incidence of adverse reactions, which deserves clinical application.