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目的探索米索前列醇口服对于宫颈软化的效果,为临床治疗提供最佳给药途径。方法选取2015年3月~2016年3月我院妇科收治的90例择期行宫腔镜手术的患者,根据自愿选择给药途径分为对照组和观察组,观察组口服给予米索前列醇,剂量为400μg;对照组于术前12 h放置海藻棒。观察并比较两组患者宫颈软化效果和药物不良反应发生情况。结果观察组的宫颈软化效果明显优于对照组,差异有统计学意义(P<0.05);观察组患者的手术镇痛效果及手术时间均明显优于对照组,差异有统计学意义(P<0.05);两组患者的不良反应发生率差异无统计学意义(P>0.05),而观察组患者不良反应改善时间明显短于对照组(P<0.05)。结论米索前列醇口服给药的宫颈软化效果良好,同时也存在一些药物的不良反应。
Objective To explore the effect of misoprostol on cervical softening and provide the best route for clinical treatment. Methods From March 2015 to March 2016, 90 patients undergoing hysteroscopic surgery undergoing gynecology in our hospital were divided into control group and observation group according to voluntary choice of administration route. The observation group was given misoprostol orally, and the dose 400μg; control group before 12 h placed seaweed rod. Observed and compared the two groups of patients with cervical softening effect and adverse drug reactions. Results The cervical softening effect in the observation group was significantly better than that in the control group (P <0.05). The analgesic effect and operation time in the observation group were significantly better than those in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05), while the adverse reaction time in the observation group was significantly shorter than that in the control group (P <0.05). Conclusions Misoprostol is effective in cervical softening when administered orally, and there are also adverse effects of some drugs.