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本文报告亚硒酸钠对小鼠骨髓细胞染色体畸变率和微核率的影响。试验剂量为1/2LD_(50)(5mg/kg)、1/10LD_(50)(1mg/kg)、1/20LD_(50)(0.5mg/kg)。结果表明亚硒酸钠剂量为5mg/kg、1mg/kg 引起小鼠骨髓细胞染色体畸变;微核试验各试验剂量与阴性对照比较均有显著性差异。表明亚硒酸钠对小鼠骨髓细胞染色体有损伤作用。
This paper reports the effect of sodium selenite on chromosome aberration rate and micronucleus rate of bone marrow cells in mice. The test dose was 1/2 LD_(50) (5 mg/kg), 1/10 LD_(50) (1 mg/kg), 1/20 LD_(50) (0.5 mg/kg). The results showed that sodium selenite doses of 5 mg/kg and 1 mg/kg caused chromosomal aberrations in mouse bone marrow cells; there were significant differences between the experimental doses of micronucleus test and negative controls. Shows that sodium selenite has a damaging effect on the chromosome of mouse bone marrow cells.