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Danazol(17αPregna-4-en-20yno[2,3-d]isoxazole-17-ol)抑制啮齿动物、恒河猴和人类的垂体促性腺激素的分泌。口服时,这种新型类周醇,既不属于雌激素或孕酮类,而是具有弱的,阻碍雄激素的作用。Danazol治疗子宫内膜异位症是有效的。它对所有动物的促性腺激素分泌的抑制以及对鼠类受孕和妇女排卵的抑制提示,这种药物可能成为一种有效的口服避孕药。本文详细介绍一种用恒河猴检定抗生育效能的快速有效实验程序。实验证明danazol对恒河猴是一种有效的口服
Danazol (17αPregna-4-en-20yno [2,3-d] isoxazole-17-ol) inhibits the secretion of pituitary gonadotropins in rodents, macaques and humans. When taken orally, this new class of phenols, neither estrogen or progesterone, but with weak, hinder the role of androgens. Danazol is effective in treating endometriosis. Its inhibition of gonadotropin secretion in all animals and its inhibition of mouse conception and ovulation in women suggest that this drug may be a potent oral contraceptive. This article details a quick and effective experimental procedure for testing anti-fertility efficacy in rhesus monkeys. Experiments show that danazol is a potent oral agent for rhesus monkeys