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作者自1983年2月将体外授精-胚胎移植(IVF-ET)用于治疗严重输卵管性不孕和难治性男性不孕已获一些经验,介绍如下。一、IVF-ET 的要点:①为了多取卵采用诱发排卵;②监测卵泡发育;③确定取卵时期;④确定停止取卵;⑤取卵;⑥卵子成熟度判定及前培养;⑦精子的调制及授精;⑧培养;⑨胚胎移植;⑩黄体期的管理。二、诱发排卵:诱发排卵可比自然排卵多获得卵子。为供胚胎移植,从开展 IVF-ET 起就采用诱发排卵。其方法有二:①Clomiphene-HCG 法(1983年2月至1984年5月),是于月经周期5～9天给药;②Clomiphene-HMG-HCG 法(1983年12月起),于月经周期3～7天,每日口服 Clomiphene citrate100mg,从第7天起肌注 HMG150～300IU,连注3～
The authors have gained some experience with IVF-ET in the treatment of severe tubal infertility and refractory male infertility since February 1983, as described below. First, the main points of IVF-ET: ① in order to take more eggs to induce ovulation; ② monitoring of follicular development; ③ determine the time of ovulation; ④ determine to stop ovulation; ⑤ ovum; ⑥ egg maturation and pre-culture judgment; Modulation and insemination; ⑧ training; ⑨ embryo transfer; ⑩ luteal phase management. Second, induced ovulation: ovulation induced ovulation more than natural ovulation. For embryo transfer, ovulation induction is initiated from IVF-ET. The method has two: ① Clomiphene-HCG method (February 1983 to May 1984), is administered in the menstrual cycle 5-9 days; ② Clomiphene-HMG-HCG method (since December 1983), in the menstrual cycle 3 ~ 7 days, daily oral Clomiphene citrate100mg, from the 7th day intramuscular injection of HMG150 ~ 300IU, and even note 3 ~