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目的探讨慢性阻塞性肺疾病(COPD)患者血清可溶性髓样细胞触发受体-1(s TREM-1)与BODE指数的相关性。方法将2013年10月至2015年3月收治的182例COPD患者分为两组,稳定期COPD(SCOPD)组患者64例,急性加重期COPD(AECOPD)组118例;健康体检者50例作为健康对照组。测定3组的血清s TREM-1水平,测定COPD患者BODE指数的各项指标并计算BODE指数评分。血清s TREM-1水平与BODE指数评分的相关性分析采用Pearson相关性检验。结果 SCOPD、AECOPD组与健康对照组各指标比较均有统计学差异(P均<0.05)。SCOPD和AECOPD组患者血清s TREM-1水平无统计学差异(P>0.05)。SCOPD组和AECOPD组患者BODE指数评分比较有统计学差异(P<0.05)。将182例COPD数据综合起来进行分析总的BODE指数与血清s TREM-1的相关性,血清s TREM-1与BODE指数评分正相关(r=0.443,P<0.01)。结论血清s TREM-1水平不随COPD状态而明显变化,而与BODE指数有关。血清s TREM-1水平检测可以大致判断BODE指数的状态。
Objective To investigate the correlation between serum sTREM-1 and BODE in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 182 patients with COPD admitted from October 2013 to March 2015 were divided into two groups: 64 patients in stable COPD (SCOPD) group and 118 patients in acute exacerbation COPD (AECOPD) group; 50 patients Healthy control group. Serum levels of TREM-1 were measured in three groups. The indexes of BODE index in COPD patients were measured and BODE index was calculated. Pearson correlation test was used to analyze the correlation between serum s-TREM-1 level and BODE index score. Results The SCOPD, AECOPD group and healthy control group each index were statistically significant (P all <0.05). There was no significant difference in serum TREM-1 levels between SCOPD and AECOPD patients (P> 0.05). There was significant difference in BODE index between SCOPD group and AECOPD group (P <0.05). A total of 182 COPD data were collected to analyze the association between total BODE index and serum s TREM-1. Serum s TREM-1 was positively correlated with BODE index (r = 0.443, P <0.01). Conclusion Serum TREM-1 levels did not change significantly with the state of COPD, but with the BODE index. Serum TREM-1 levels can roughly determine the status of the BODE index.