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目的研究糖化血红蛋白(H b A 1 c)联合超敏C反应蛋白(H s-C P R)在妊娠期糖尿病(G D M)诊断的早期临床预测价值。方法对照组1 1 0例,G D M组7 2例,检测不同孕周的H b A 1 c、H s-C P R血清水平。结果两组H b A 1 c、H s-C P R血清水平不同孕周组内无差异,组间经方差分析差异均有统计学意义(P<0.0 5);两组H b A 1 c、H s-C P R的异常率差异有统计学意义(P<0.0 5);联合检测的特异性和阳性预测值明显高于两者单独检测结果(P<0.0 5)。结论 H b A 1 c联合H s-C P R的检测对妊娠糖尿病早期诊断有重要的临床预测意义。
Objective To investigate the early clinical value of HbA 1 c combined with Hs-C P R in the diagnosis of gestational diabetes mellitus (G D M). Methods One hundred and ten patients in the control group and 72 in the GDM group were enrolled in this study. The serum levels of HbA1c and Hs-C P were measured at different gestational weeks. Results There was no significant difference in serum levels of HbA1c and HsCPR between the two groups in gestational age group. There was significant difference between the two groups in variance analysis (P <0.05). HbA1c, HsC The abnormal rate of PR was significantly different (P <0.0 5). The specificity and positive predictive value of combined detection were significantly higher than those of PR alone (P <0.0 5). Conclusion The detection of HbA1c combined with Hs-C P R has important clinical predictive value in the early diagnosis of gestational diabetes mellitus.