Available irrigation resources are becoming increasingly scarce in the North China Plain (NCP), and nitrogen-use efficiency of crop production is also relatively low. Thus, it is imperative to improve the water-use efficiency (WUE) and nitrogen fertilizer productivity on the NCP. Here, we conducted a two-year field experiment to explore the effects of different irrigation amounts (S60, 60 mm; S90, 90 mm; S120, 120 mm; S150, 150 mm) and nitrogen application rates (150, 195 and 240 kg ha–1; denoted as N1, N2 and N3, respectively) under micro-sprinkling with water and nitrogen combined on the grain yield (GY), yield components, leaf area index (LAI), flag leaf chlorophyll content, dry matter accumulation (DM), WUE, and nitrogen partial factor productivity (NPFP). The results indicated that the GY and NPFP increased significantly with increasing irrigation amount, but there was no significant difference between S120 and S150; WUE significantly increased first but then decreased with increasing irrigation and S120 achieved the highest WUE. The increase in nitrogen was beneficial to improving the GY and WUE in S60 and S90, while the excessive nitrogen application (N3) significantly reduced the GY and WUE in S120 and S150 compared with those in the N2 treatment. The NPFP significantly decreased with increasing nitrogen rate under the same irrigation treatments. The synchronous increase in spike number (SN) and 1000-grain weight (TWG) was the main reason for the large increase in GY by micro-sprinkling with increasing irrigation, and the differences in SN and TGW between S120 and S150 were small. Under S60 and S90, the TGW increased with increasing nitrogen application, which enhanced the GY, while N2 achieved the highest TWG in S120 and S150. At the filling stage, the LAI increased with increasing irrigation, and greater amounts of irrigation significantly increased the chlorophyll content in the flag leaf, which was instrumental in increasing DM after anthesis and increasing the TGW. Micro-sprinkling with increased amounts of irrigation or excessive nitrogen application decreased the WUE mainly due to the increase in total water consumption (ET) and the small increase or decrease in GY. Moreover, the increase in irrigation increased the total nitrogen accumulation or contents (TNC) of plants at maturity and reduced the residual nitrate-nitrogen in the soil (SNC), which was conducive to the increase in NPFP, but there was no significant difference in TNC between S120 and S150. Under the same irrigation treatments, an increase in nitrogen application significantly increased the residual SNC and decreased the NPFP. Overall, micro-sprinkling with 120 mm of irrigation and a total nitrogen application of 195 kg ha–1 can lead to increases in GY, WUE and NPFP on the NCP.