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抗生素８９－０７是庆大霉素新型的衍生物，给大鼠肌注３０、９０和１２０ｍｇ／ｋｇ，每日１次，为期７ｄ或２１ｄ，并与庆大霉素（ＧＭ）等剂量进行肾毒性比较，结果表明，ＧＭ１２０ｍｇ／ｋｇ组引起大鼠肾功能的损害包括尿蛋白、尿糖、尿酶的活性，一般毒性症状和体重增长受抑制比抗生素８９－０７等剂量严重。病理组织学检查证明，ＧＭ和抗生素８９－０７的９０和１２０ｍｇ／ｋｇ剂量主要是肾近曲小管上皮细胞损伤，抗生素８９－０７仅有轻度近曲小管上皮细胞退行性改变，而ＧＭ除细胞退行变性外，有部分细胞坏死，肾小管内有蛋白管型和细胞管型。
Antibiotics 89-07, a novel gentamicin derivative, were intramuscularly injected to rats at 30, 90 and 120 mg / kg once daily for 7 days or 21 days and were given equal doses of gentamicin (GM) Toxicity, the results showed that GM120mg / kg group caused renal damage in rats including urinary protein, urine glucose, urinary enzyme activity, general toxicity and weight gain were inhibited than other antibiotics 89-07 and other doses. Histopathological examination showed that the doses of 90 and 120 mg / kg of GM and antibiotic 89-07 were mainly renal proximal tubule epithelial cell injury, with only mild mild proximal tubule epithelial cell degeneration in antibiotic 89-07, Degenerative degeneration, there are some cells necrosis, tubular and tubular protein tube.