在235例重型布魯氏菌病患者使用了布魯氏菌苗皮内注射。本方法的实質在于当皮内注射抗原时發現免疫性形成较之皮下注射同一抗原时迅速而持久。同时当皮內注射时,起决定性作用的并不是抗原的数量,而是皮膚部位的广泛性以及参与免疫过程的皮肤神经末梢。方法如下:1毫升含有10亿个菌体的菌苗,稀釋于100毫升無菌生理鹽水中。如果局部反应很显 Brucella vaccines were injected intradermally in 235 patients with severe brucellosis. The essence of the method is that it is rapid and long-lasting when compared to the subcutaneous injection of the same antigen when the antigen is injected intradermally. At the same time, when the intradermal injection, the decisive role is not the number of antigens, but the extensive part of the skin and the skin nerve endings involved in the immune process. The method is as follows: 1 ml of bacteria containing 1 billion bacteria, diluted in 100 ml of sterile saline. If the local reaction is significant