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N-乙酰-β-氨基葡萄糖甙酶(简称 NAG)存在于细胞溶酶体内,其生理作用与水解糖蛋白和脂蛋白分子内的葡萄糖甙有关。正常人尿中可有少量 NAG 存在,主要来自肾小管上皮细胞的溶酶体。早在1967年 Robinson 等就发现肾毒性物质可使动物尿 NAG 增高。以后尿 NAG 的测定被应用于对移植肾排异反应的监护。近年来国外已将其列入肾脏疾病的常规实验室项目。正常人尿中的 NAG以往认为正常人尿中不存在 NAG,只有在肾脏疾病时才出现。由于测定方法灵敏度提高,才发现正常人尿中也有此酶活力存在。因为肾组织中 NAG 的含量与肾实质的体积有
N-acetyl-β-glucosaminidase (NAG) exists in the cell lysosome, its physiological role and hydrolysis of glycoproteins and lipoprotein molecules within the glucoside related. Normal human urine may have a small amount of NAG, mainly from renal tubular epithelial cells lysosome. As early as 1967, Robinson et al. Found that nephrotoxic substances can increase urinary NAG in animals. After the determination of urinary NAG was applied to the monitoring of renal allograft rejection. In recent years, foreign countries have included it in routine laboratory projects of kidney disease. Normal human urine NAG in the past that normal urine does not exist in the NAG, only when kidney disease occurs. Due to the increased sensitivity of the assay, it was found that this enzyme activity exists in normal human urine. Because the content of NAG in renal tissue and renal parenchyma volume