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芳基二甲基三氮烯类是一系列具有抗肿瘤、实验性致突变和致癌活性化合物。近年研究表明,某些咪唑和苯基取代的三氮烯化合物在小鼠皮下接种Lewis 肺癌中显示其选择性的抗脾转移活性。它们通过对肿瘤细胞产生细胞毒性和选择性的抗转移作用来阻止转移灶的形成,而这两种作用均取决于化合物结构的差异。因而有必要对图1所示结构的一系列芳基二甲基三氮烯化合物用定量构一效关系方法对其产生的不同作用进行研究。
Aryldimethyltriazines are a series of compounds that are anti-tumor, experimental mutagenic and carcinogenic. Recent studies show that certain imidazole and phenyl-substituted triazene compounds show selective anti-spleen metastatic activity in mice bearing Lewis lung carcinoma subcutaneously. They prevent the formation of metastases by producing cytotoxic and selective anti-metastatic effects on tumor cells, both of which depend on differences in the structure of the compounds. Therefore, it is necessary to study the different effects of a series of aryl dimethyl triazene compounds of the structure shown in FIG. 1 by a quantitative structure-activity relationship method.