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上海交通大学医学院生物化学与细胞生物学系研究人员揭示蛋白质修饰调控初始miRNA(pri-miRNA)直接介导基因沉默效应的分子机制上海交通大学医学院生物化学与细胞生物学系余健秀教授领衔的研究组在miRNA作用机制研究中取得新进展,在国际上首次发现DGCR8的类泛素化修饰(SUMO化修饰)调控初始miRNA(pri-miRNA)直接介导基因沉默效应的分子机制。这项研究成果以“SUMOylation at K707 of DGCR8 controls direct function of primary microRNA”为题于7月21日在国际著名学术
Researchers at Department of Biochemistry and Cell Biology, School of Medicine, Shanghai Jiaotong University, Shanghai, China Reveal Molecular Mechanisms for Protein Modification to Directly Regulate Gene Silencing by Primer miRNAs Title Professor Yu Jianxiu, Department of Biochemistry and Cell Biology, School of Medicine, Shanghai Jiao Tong University Of the research group made new progress in the study of miRNA mechanism of action, the first time in the world found that DGCR8 ubiquitination modification (SUMOylation) regulation of the initial miRNA (pri-miRNA) directly mediated molecular gene silencing effect. The research results in the “SUMOylation at K707 of DGCR8 controls direct function of primary microRNA ” on July 21 in the international famous academic