论文部分内容阅读
目的检测RhoC在胃癌中的表达,探讨其临床病理学意义。方法应用免疫组化SP法检测73例胃癌组织的RhoC蛋白表达,分析其与胃癌浸润转移的关系。结果RhoC蛋白在胃癌组织中的表达高于周围组织,组间比较均有统计学差异(P<0.05)与胃癌浸润程度、淋巴结转移及临床分期均密切相关(P<0.05),与胃癌患者性别、年龄及分化无关(P>0.05)。结论MMP-9和VEGF在大肠腺癌组织中的表达和浸润深度、淋巴结转移有关,和分化无关,两者的表达具有相关性。RhoC参与胃癌的浸润转移,抑制其表达对胃癌有一定治疗作用。
Objective To detect the expression of RhoC in gastric carcinoma and to explore its clinicopathological significance. Methods The expression of RhoC protein in 73 cases of gastric carcinoma was detected by immunohistochemical SP method. The relationship between the expression of RhoC and the infiltration and metastasis of gastric carcinoma was analyzed. Results The expression of RhoC protein in gastric cancer tissues was higher than that in the surrounding tissues (P <0.05). There was a significant correlation between the expression of RhoC protein and the infiltration of gastric cancer, lymph node metastasis and clinical stage (P <0.05) , Age and differentiation (P> 0.05). Conclusions The expression of MMP-9 and VEGF in colorectal adenocarcinoma is related to the depth of invasion and lymph node metastasis, but not to the differentiation. The expression of MMP-9 and VEGF is correlated with the expression of MMP-9 and VEGF. RhoC is involved in invasion and metastasis of gastric cancer and inhibiting the expression of RhoC has a certain therapeutic effect on gastric cancer.