尿激酶型纤溶酶原激活剂u-PA(urokinase-type plasminogen activator)属于丝氨酸蛋白酶类,能激活细胞外基质中丰富的纤溶酶原生成纤溶酶,从而催化细胞外基质降解,对纤溶和癌细胞侵染及扩散等一系列生理和病理过程中发生的胞外蛋白水解起重要调节作用。 人u-PA基因位于第10号染色体之上,表达产生一个约54kD的单链糖基化多肽——尿激酶原。尿激酶原经纤溶酶在其158位赖氨酸 Urokinase-type plasminogen activator u-PA (urokinase-type plasminogen activator) belongs to the class of serine proteases, can activate the extracellular matrix of plasminogen-rich plasminogen, thereby catalyzing the degradation of extracellular matrix, fiber Dissolution and cancer cell infection and proliferation and a series of physiological and pathological processes occur in extracellular proteolysis play an important regulatory role. The human u-PA gene is located on chromosome 10 and expresses an about 54 kD single-chain glycosylated polypeptide, prourokinase. Pro-urokinase is lysine at its 158 position via plasmin